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LIFE RISKS - PROJECT SUMMARY

Host factors involved in Chikungunya virus infection

Delphine JUDITH, AXA Research Fellow

Support by the AXA Research Fund

TYPE OF SUPPORT GRANTED AMOUNT DURATION
Doctoral Fellowships 120,000 3 years

Project Informations

Changing Climate, Emerging Disease

Climate change may impact certain diseases, carried by insects to new regions of the planet. Chikungunya virus (CHIKV), for example, is poised to spread globally via its mosquito vector, now present on nearly every continent. Judith studies the precise mechanisms of CHIKV infection. She has revealed how parts of our cellular machinery can block or actually encourage virus replication. This knowledge could improve lab models of the disease, enhancing the search for new treatments and prevention methods.

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Biography

I earned a Bachelor’s Degree in chemistry, biology and biophysics from the University of Paris 5, and a Master’s Degree in infectiology, microbiology, virology and immunology from the University of Paris 7. In September 2008, I began my PhD project in virology at the Institut Pasteur within the group directed by Professor Marc Lecuit (Microbes and host barriers, Inserm avenir and Institut Pasteur). My work focuses on the cell biology of Chikungunya virus infection.

Research work

My research focuses on a virus transmitted by mosquito bites, known as Chikungunya virus (CHIKV). Chikungunya virus is an arbovirus that has recently re-emerged and is responsible for a massive outbreak in the Indian Ocean region and India. It has a very significant potential to spread globally given the expanding distribution of its mosquito vectors in the contexts of globalisation and global warming. CHIKV induces a mild disease in humans characterised by fever, arthralgia, myalgia and rash, but cases of severe CHIKV infection have also been described, particularly in adults with underlying conditions and neonates born to viremic mothers.
My project focuses on the cell biology of the infection. More specifically, I intend to decipher the molecular mechanisms underlying CHIKV’s entry into target cells and its dissemination to neighbouring cells. This project should not only enrich our basic understanding of the biology of this poorly characterised virus, but should also help define new therapeutic and preventive strategies.

AXA Fellowship

Being selected as a recipient of the AXA Fellowship has provided me with the necessary funding to complete my PhD. This prestigious award will also foster recognition of the quality and general interest of my research. This award illustrates AXA’s interest in basic science and how investment in basic science translates into minimising the risks associated with emerging infections and global warming.


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