Direct intercellular transfer of Chikungunya virus
Delphine JUDITH, AXA Research Fellow
Support by the AXA Research Fund
TYPE OF SUPPORT
earned a Bachelor’s Degree in chemistry, biology and biophysics from the
University of Paris 5, and a Master’s Degree in infectiology, microbiology,
virology and immunology from the University of Paris 7. In September 2008, I
began my PhD project in virology at the Institut Pasteur within the group
directed by Professor Marc Lecuit (Microbes and host
barriers, Inserm avenir and Institut Pasteur). My work focuses on the cell
biology of Chikungunya virus infection.
My research focuses on a virus
transmitted by mosquito bites, known as Chikungunya virus (CHIKV). Chikungunya
virus is an arbovirus that has recently re-emerged and is responsible for a
massive outbreak in the Indian Ocean region and India. It has a very
significant potential to spread globally given the expanding distribution of
its mosquito vectors in the contexts of globalisation and global warming. CHIKV induces a mild disease in humans
characterised by fever, arthralgia, myalgia and rash, but cases of severe CHIKV
infection have also been described, particularly in adults with underlying
conditions and neonates born to viremic mothers.
My project focuses on the cell
biology of the infection. More specifically, I intend to decipher the molecular
mechanisms underlying CHIKV’s entry into target cells and its dissemination to
neighbouring cells. This project should not only enrich our basic
understanding of the biology of this poorly characterised virus, but should also
help define new therapeutic and preventive strategies.
Being selected as a recipient of the
AXA Fellowship has provided me with the necessary funding to complete my PhD.
This prestigious award will also foster recognition of the quality and general
interest of my research. This award illustrates AXA’s interest in basic science
and how investment in basic science translates into minimising the risks
associated with emerging infections and global warming.
To add or modify information on this page, please contact us at the following address:
Back to previous page