Year of selection 2021
Institution The University of Queensland – Queensland Alliance for Environmental Health Sciences
Every year, ten million new substances are developed and introduced to the market, exposing humans to an ever-expanding range of chemicals with unknown long-term impacts on their health. These chemicals, which include pharmaceuticals, personal care products, pesticides, and so on, can be regarded as contaminants of emerging concern (CECs) based on their toxicity and impact on health or the environment. Chemical pollutants are responsible for at least 10% of all human deaths and diseases, according to the World Health Organization. However, due to the difficulty of quantifying and assessing the effects of chemicals on the human body, this figure is likely to be underestimated.
Human biomonitoring (HBM) allows the assessment of human exposure to chemicals, by measuring chemicals and their concentration in human tissues (blood, hair, breastmilk, etc.). HBM data enables evidence-informed policy to reduce risk to human health. To be accurate and effective, HBM must first understand how chemicals of interest are metabolized and how they interact with cells or molecules in the body. Furthermore, it is vital to sample, identify and measure a greater number of biomarkers than what is currently possible, particularly contaminants of emerging concern (CECs). Existing HBM programs are limited and can only evaluate a tiny fraction of the chemicals in use due to a lack of biomarkers and assessment methods for the majority of chemicals.
During his AXA Fellowship at the University of Queensland (Australia), Dr. Chang He seeks to address the gap in HBM programs by developing a systematic method for assessing human exposure to hazardous pollutants while employing a human biomonitoring strategy. As there are few biomarkers available for human biomonitoring, only a few chemicals have been evaluated to date. One of the primary goals of this project is to identify biomarkers for additional chemicals using in silico, in vitro, and in vivo models and use these biomarkers to assess human exposure to various pollutants.
With this research, Dr. Chang He aims to make the chemical industry safer and more sustainable, with the ultimate objective of improving human and environmental health. Through the identification of biomarkers for emerging contaminants and the safety assessment of these emerging contaminants, his research is expected to provide insights into which chemicals should be monitored, and whether their production and use should be prohibited on a national and global scale. The identified biomarkers and developed analytical method will also be applied to the Australian population to assess the exposure to contaminants of emerging concern, utilizing the University of Queensland’s unique environmental and human specimen banks that were established decades ago.
 World Health Organization, Global health risks: mortality and burden of disease attributable to selected major risks. 2009.