Year of selection 2017
Institution Université de Bordeaux
In the hippocampus – a deeply-embedded part of the brain that plays a key role in memory formation –, neurones communicate together via tiny protrusions called dendritic spines. Predictably, dysfunctional spines are involved in neurodegenerative diseases such as Alzheimer’s (AD). To allow for a better understanding of the mechanisms at work at this level, Dr. Stéphane Bancelin, of the University of Bordeaux, is adapting recent advances in super-resolution microscopy for the purpose of visualising hippocampal spines in vivo. His results may ultimately contribute to earlier AD diagnosis and lead to the identification of new therapeutic targets.