|Year of selection||2010|
|Institution||INSERM - Genetics and Development Institute|
Type of support
120 000 €
Ridding Drugs of Undesired Side Effects
Undesired side effects, which threaten both patients and pharmaceutical companies, sometimes occur when a drug designed for a particular purpose affects proteins carrying unexpected functions. Benoît Robisson aims to identify such moonlighting proteins.
Research on side-effects of drugs became an important subject of studies in the pharmaceutical field. Side-effects may be encountered when the chosen drug target is a moonlighting protein (i.e. protein with several unrelated functions). Therefore, this kind of proteins remains widely unknown, and there is a need to develop a method to identify them. We propose a large-scale and without a priori method based on the partitioning of protein-protein interactions networks. Proteins interact to perform there functions, and the partitioning group in a same class proteins involved in a same biological process. Then, proteins find at the intersection of several classes are good moonlighting proteins candidates.
To add or modify information on this page, please contact us at the following address: email@example.com